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By Dietmar Richter

Selective cytoplasmic organelle and protein focusing on has lengthy been suggestion to represent the only real determinant of phone polarity and complexity. This view has been replaced, notwithstanding, through the invention of differential subcellular RNA distribution styles. during the last decade it has turn into transparent that selective mRNA sorting and translation contributes to an accumulation of cognate proteins at discrete mobile websites. during this booklet, a number of platforms are mentioned (e.g. Xenopus oocytes, mammalian mind, invertebrate fearful procedure) when it comes to RNA trafficking, RNA-targeting sequences (cis-elements) and RNA-transporting proteins (trans-factors), activity-dependent translational legislation and the importance of the cytoskeleton for neuronal functionality and plasticity. It additionally discusses nucleocytoplasmic export of mRNA and viral RNA as one other instance of subcellular RNA kinesis.

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Cell Polarity and Subcellular RNA Localization (Results and Problems in Cell Differentiation) by Dietmar Richter

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